Tejero, Tomas et al. published their research in Tetrahedron in 1997 | CAS: 94594-91-9

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.COA of Formula: C13H19NO3S

1,3-Dipolar cycloaddition of C-(2-thiazolyl)nitrones to chiral acrylates. Synthesis of enantiopure α-amino-2-alkylthiazoles and 5-formylpyrrolidin-2-ones was written by Tejero, Tomas;Dondoni, Alessandro;Rojo, Isabel;Merchan, Francisco L.;Merino, Pedro. And the article was included in Tetrahedron in 1997.COA of Formula: C13H19NO3S This article mentions the following:

The 1,3-dipolar cycloaddition of thiazolyl nitrones I (R1 = PhCH2, 4-MeOC6H4CH2) with chiral acrylates, e.g., II, has been studied. The use of the Oppolzer’s camphor sultam as chiral inductor provided isoxazolidines, III with excellent regio- and diastereoselectivities and good asym. induction. The cycloadducts were converted into homochiral α-amino-2-alkylthiazoles and 5-(2-thiazolyl)-3-hydroxy-2-pyrrolidinones IV. The latter compounds were precursors of highly functionalized pyrrolidones by the aldehyde unmasking from the thiazole ring and subsequent reactions of the formyl group. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9COA of Formula: C13H19NO3S).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.COA of Formula: C13H19NO3S

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com