Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors was written by Shibue, Taku;Hirai, Toshihiro;Okamoto, Iwao;Morita, Nobuyoshi;Masu, Hyuma;Azumaya, Isao;Tamura, Osamu. And the article was included in Tetrahedron Letters in 2009.Related Products of 94594-91-9 This article mentions the following:
Synthetic studies of two components of tubulysins, tubulin polymerization inhibitors are described. The highly stereoselective synthesis of tubuvaline Me ester I was accomplished by 1,3-dipolar cycloaddition of nitrone and acrylic acid derivatives as a key step. The synthesis of tubuphenylalanine II was conducted by an aldol reaction of a boron enolate of (S)-4-isopropyl-3-propionyl-2-oxazolidinone with aldehyde, readily prepared from phenylalanine, followed by Barton deoxygenation under radical conditions. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Related Products of 94594-91-9).
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Related Products of 94594-91-9
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com