Day: February 23, 2023

Synthetic studies on the immunosuppressive agent FK-506: enantioselective synthesis of a C22-C34 fragment was written by Baker, Robert K.;Rupprecht, Kathleen M.;Armistead, David M.;Boger, Joshua;Frankshun, Robert A.;Hodges, Paul J.;Hoogsteen, Karst;Pisano, Judith M.;Witzel, Bruce E.. And the article was included in Tetrahedron Letters in 1998.Synthetic Route of C13H19NO3S This article mentions the following:

The C28-C32 cyclohexyl group of the natural product, FK-506 (I), was prepared enantioselectively from the iodolactone II by replacement of iodide with retention of configuration. The C27-C28 trisubstituted olefin was introduced stereoselectively via a classical aldol/elimination sequence employing titanium enolate methodol. Elaboration of this chem. has led to a synthesis of C22-C34 fragment III of the natural product. In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7Synthetic Route of C13H19NO3S).

1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.Synthetic Route of C13H19NO3S

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Study on the formulation of stabilizer municipal sewage after treatment by membrane bioreactor was written by Zou, Haiming;Li, Fenru;Wang, Qingsheng;Zhao, Jianrong. And the article was included in Mo Kexue Yu Jishu in 2010.Formula: C3H3NOS This article mentions the following:

The formulated municipal sewage is used as circulating cooling water for power plant. In this paper, water treatment agent for power plants was selected by static experiment and dynamic simulated test. Mechanism of scaling and corrosion inhibition of compound drugs was studied. The results show that new effective scaling and corrosion inhibitor, named BF-2, is an excellent water treatment reagent and scaling inhibiting rate is 93.6% at the concentration of 10.0 mg/L, which show that it is feasible for domestic wastewater to reuse. The study can provides preference for reusing domestic wastewater treated for circulating cooling water of power plant. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Formula: C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.Formula: C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Modeling mould growth on coated modified and unmodified wood substrates exposed outdoors was written by Gobakken, Lone Ross;Lebow, Patricia K.. And the article was included in Wood Science and Technology in 2010.Product Details of 1003-07-2 This article mentions the following:

Mold growth on coated wood is today a genuine challenge for house owners. Environmentally sound wooden facades with long service lives and acceptable appearance are desired. The objective in this study was to investigate the accumulated mold growth on 13 different wood substrates with 3 surface coating systems by identifying the factors that contribute to the variation and to predict future performance. A generalized linear mixed model was fit to the data with the anal. showing that coating and exposure time both had highly significant influences on mold growth. Further, wood substrate was significant, but comparatively less than coating and exposure time. A smaller coefficient for mold coverage in the beginning of the exposure period gave the panels with one of the coating systems, BAP, a delay in mold growth, and the extrapolated values for years 6-12 indicate a longer aesthetic service life than panels with the two other coating systems. Coated heartwood as wood type was less susceptible to mold growth than coated mixed wood and coated sapwood. Acetylated pine as wood substrate and aspen as wood species had lower resistance to mold growth than the other wood substrates and wood species, resp. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Product Details of 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Long-lasting isothiazolinone-based biocide obtained by encapsulation in micron-sized mesoporous matrices was written by Mardones, Lucas E.;Legnoverde, Maria S.;Pereyra, Andrea M.;Basaldella, Elena I.. And the article was included in Progress in Organic Coatings in 2018.Product Details of 1003-07-2 This article mentions the following:

The physicochem. properties of the silicas (structure, textural properties) were evaluated by SEM, TEM, XRD and adsorption/desorption of N₂ in order to determine their ability to encapsulate, stabilize and subsequently release a com. biocide used for latex preservation (CMIT/MIT). CMIT/MIT consists of an aqueous solution of the active ingredients CMIT (5-chloro-2-methyl-4-isothiazolin-3-one) and MIT (2-methyl-4-isothiazolin-3-one), present in a CMIT/MIT: 3/1 wt ratio. MCF has less hindered diffusion caused by a short channel length, which facilitates the biocide access to the pores of the matrix. The long pore length of SBA-15 makes the diffusion of CMIT/MIT mixture more difficult. Biocide release tests in aqueous media indicated that the CMIT/MIT concentration in the leaching solution depends on the matrix nature, the smaller values being obtained when the ordered matrix was used. Addnl., biocide delivery could be delayed by increasing the working pH from 7 to 9. Results showed that biocide encapsulation allows maintaining a long-lasting release, even under alk. conditions (pH 9), at which the hydrolysis of non-supported CMIT occur. Several release tests at different temperature (318, 323 and 328 K), were carried out for 20 days at pH 7. The biocide loading after the tests was reflected in the IR spectra, and it has been corroborated that biocide encapsulation allows retarding the fast thermal decomposition of CMIT. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Product Details of 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

High-yield synthesis of pyrrolidinyl PNA monomers was written by Merino, Pedro;Greco, Graziella;Tejero, Tomas;Chiacchio, Ugo;Corsaro, Antonino;Pistara, Venerando;Romeo, Giovanni. And the article was included in Tetrahedron Letters in 2011.Product Details of 94594-91-9 This article mentions the following:

Two monomers for the syntheses of conformationally restricted peptide nucleic acids were synthesized through a simple procedure, involving an asym. 1,3-dipolar cycloaddition chem. as a key step, from common starting materials in 3 and 5 steps, and 58.8% and 30.5% overall yields, resp. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Product Details of 94594-91-9).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. In general, isothiazole undergoes nitration in the presence of HNO3, sulfuric acid, and sulfonation by using sulfuric acid under thermal conditions to generate corresponding 4-nitro- and 4-sulfonic acid derivatives, respectively.Product Details of 94594-91-9

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Electro-kinetic washing of a soil contaminated with quinclorac and subsequent electro-oxidation of wash water was written by Vidal, J.;Baez, Maria E.;Salazar, R.. And the article was included in Science of the Total Environment in 2021.Related Products of 1003-07-2 This article mentions the following:

This work deals with the remediation of a soil that has been enriched with Quinclorac (QNC), one of the herbicides most used in Chile for weed control in rice fields. Quinclorac damages the microflora and macrofauna of soils and is toxic to some susceptible crops, which results in economic loses during crop rotation. Furthermore, Quinclorac a potential contaminant of water resources and soils, given its high mobility and persistence. This has created the need to lower its concentrations in soils intensively cultivated. In this study, an electro-kinetic soil washing system (EKSW) for mobilizing this pesticide in the soil was explored. The performance of this technol. was compared by assessing the effect of direct (DP) and reverse (RP) polarity during 15 days under potentiostatic conditions and applying an elec. field of 1 V cm-1 between electrodes. Among the main results, the highest removal of QNC was obtained through the EKSW-RP process, which also contributed to the prevention of acidity and alk. fronts in the soil, compared to the EKSW-DP system. In both cases, the highest accumulation of QNC occurred in the cathodic well by mobilizing the non-ionized contaminant through the electroosmotic flow (EOF) from anode to cathode. After the treatment with EKSW, the wash water accumulated in the anodic and cathodic wells, which contained an important concentration of pesticide, was subjected to electro-oxidation (EO) by applying different current densities (j). The high generation of •OH on the surface of a boron-doped diamond electrode (BDD) allowed for the complete degradation and mineralization of QNC and its major intermediate compounds to CO₂. The results of this study show that the application of both coupled stages in this type of remediation technologies would enable the removal of QNC from the soil without altering its chem. and phys. properties, constituting an environmentally friendly process. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Related Products of 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Related Products of 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Synthesis and X-ray crystal structure of a thymidine derivative was written by Kim, Su Jeong;Lee, Ju Young;Ko, Ki Hwan;Kim, Byeang Hyean. And the article was included in Bulletin of the Korean Chemical Society in 1998.Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:

A thymidine derivative has been synthesized from thymidine in 6 steps (40.5% overall yield) and X-ray crystallog. study shows that this derivative forms a centrosym. cyclic dimer through hydrogen bonding between thymine-thymine bases. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Diastereoselective cycloadditions of nitrilimines to enantiopure acrylamides was written by Garanti, Luisa;Molteni, Giorgio;Pilati, Tullio. And the article was included in Tetrahedron: Asymmetry in 2002.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:

The diastereoselective cycloaddition of the nitrilimine, generated from hydrazonoyl chloride 4-MeC₆H₄NHN:C(Cl)CO₂Me, with enantiopure pyrrolidine, oxazolidine, or camphorsultam substituted acrylamides, e.g. I (R = Me₂CH, Ph), gave separable mixtures of isomeric 4,5-dihydropyrazoles, e.g. II. Basic hydrolysis of the cycloadducts gave the corresponding dicarboxy derivatives, e.g. III, which are of potential interest as new chiral building blocks. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Arsenic uptake, transformation, and release by three freshwater algae under conditions with and without growth stress was written by Xie, Shaowen;Liu, Jinxin;Yang, Fen;Feng, Hanxiao;Wei, Chaoyang;Wu, Fengchang. And the article was included in Environmental Science and Pollution Research in 2018.Quality Control of Isothiazol-3(2H)-one This article mentions the following:

This study was carried out using indoor controlled experiments to study the arsenic uptake, biotransformation, and release behaviors of freshwater algae under growth stress. Three freshwater algae, Microcystis aeruginosa, Anabaena flosaquae, and Chlorella sp.,Two types of inhibitors, Cu²⁺ and isothiazolinone, inhibit the growth of the algae. The algae were cultivated to a logarithmic stage in growth media containing0.1 mg/L P; then,0.8 mg/LAs in the form of arsenate (iAs^V) was added,while both inhibitors were simultaneously added at dosages of 0.1 and 0.3 mg/LAfter 2 days of exposure, the average growth rate was measured to represent the growth rates of the algae cells; the extra- and intracellular monomethyl arsenic, and di-Me arsenic, were also measured,Without inhibitors,M.aeruginosa significantly higher than that of the other two algae.However, when Cu²⁺ was added as an external inhibitor, the order of the average growth rate for the three algae became partially reversed.The great reduction in M. aeruginosa growth rate was accompanied by increases in extracellular iAs^V and iAs^III and intracellular iAs concentrations The biol.productivity of As by the three algae followed the order of M.aeruginosa, Chlorella sp.,and A.flosaquae,generally consistent with the As transformation and release in conditions with and without inhibitors, suggesting that the As behavior in the algae that was related to growth stress largely differed among algae species. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Quality Control of Isothiazol-3(2H)-one).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Quality Control of Isothiazol-3(2H)-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo was written by Dayal, Neetu;Reznickova, Eva;Hernandez, Delmis E.;Perina, Miroslav;Torregrosa-Allen, Sandra;Elzey, Bennett D.;Skerlova, Jana;Ajani, Haresh;Djukic, Stefan;Vojackova, Veronika;Lepsik, Martin;Rezacova, Pavlina;Krystof, Vladimir;Jorda, Radek;Sintim, Herman O.. And the article was included in Journal of Medicinal Chemistry in 2021.Application In Synthesis of Benzo[d]isothiazol-5-amine This article mentions the following:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC₅₀ values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC₅₀ values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. In the experiment, the researchers used many compounds, for example, Benzo[d]isothiazol-5-amine (cas: 53473-85-1Application In Synthesis of Benzo[d]isothiazol-5-amine).

Benzo[d]isothiazol-5-amine (cas: 53473-85-1) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Application In Synthesis of Benzo[d]isothiazol-5-amine

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com