Evaluation of bactericidal performances of different bactericides on sulfate reducing bacteria was written by Gao, Jian-fu;Li, Jin;Jing, Chao-wen. And the article was included in Gongye Yongshui Yu Feishui in 2013.Synthetic Route of C3H3NOS This article mentions the following:
The bactericidal performances of three kinds of bactericides: NaClO, 1227 and isothiazolinone, on sulfate reducing bacteria (SRB) in circulating water were investigated by static cultivation; the changes of SRB cellular morphol. and corrosion morphol. of SS316L stainless steel test specimen were observed using SEM. The results showed that, NaClO obtained its best bactericidal performance in 12 h, which was shorter than the required time (24 h) for 1227 and isothiazolinone getting their optimal bactericidal performance. However, the antibacterial duration of NaClO was short, which was only 24 h; on the contrary, 1227 had the longest antibacterial duration, which was about 1 wk. Under the optimal conditions, the highest bactericidal rates of NaClO, 1227 and isothiazolinone reached 86.71%, 89.70% and 79.70% resp. Along with time, the cell structure of SRB was decomposed from partially to totally, and the cells disintegrated completely in 7 h. In the circulating cooling water with SRB inoculation, a layer of uneven distribution biofilm was formed on the surface of SS316L, which showed that, the corrosion of SS316L caused by SRB was mainly represented as pitting corrosion. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Synthetic Route of C3H3NOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com