Copper-Catalyzed Intermolecular Trifluoromethylazidation of Alkenes: Convenient Access to CF3-Containing Alkyl Azides was written by Wang, Fei;Qi, Xiaoxu;Liang, Zhaoli;Chen, Pinhong;Liu, Guosheng. And the article was included in Angewandte Chemie, International Edition in 2014.SDS of cas: 119944-89-7 This article mentions the following:
A novel copper-catalyzed intermol. trifluoromethylazidation of alkenes has been developed under mild reaction conditions. A variety of CF3-containing azides were directly synthesized from a wide range of olefins, including activated and un-activated alkenes, and the resulting products can be easily transformed into the corresponding CF3-containing amine derivatives Under optimized reaction conditions the synthesis of the target compounds was achieved using tetrakis(acetonitrile)copper hexafluorophosphate as a catalyst for a reaction of alkenes with trimethylsilyl azide and 3,3-dimethyl-1-(trifluoromethyl)-1,2-benzodioxol. Alkene reactants included (ethenyl)benzene derivatives (styrene), cyclopentene, cyclohexene, indene, cyclooctene, dihydroquinoline, (3β)-3-(acetyloxy)pregn-5-en-20-one, 4-methoxyphenyl 4,6-O-[(S)-phenylmethylene]-3-O-2-propen-1-yl-β-δ-galactopyranose (monosaccharide O-allyl ether), terpene derivatives In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7SDS of cas: 119944-89-7).
1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.SDS of cas: 119944-89-7
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com