The use of vicinal twofold Heck reaction products in diastereoselective sequential Michael additions. A convenient access to enantiomerically pure six-ring annulated cispentacin derivatives was written by Voigt, Katharina;Lansky, Annegret;Noltemeyer, Mathias;de Meijere, Armin. And the article was included in Liebigs Annalen in 1996.Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:
The Pd-catalyzed coupling reactions of various acrylic acid derivatives with 1,2-dibromobenzene, 1,2,3-tribromobenzene, and 1,2-dibromocyclohexene yielded the corresponding diethenylarenes I (R = OMe, OCMe3, OCH2Ph, O-menthyl, O-camphorsultamyl; R1 = H; R2R3, R4R5 = bond), triethenylarenes I [R = OMe, OCMe3; R1 = (E)-CH:CHCOR; R2R3, R4R5 = bond], and hexatrienes I (R = OMe, OCMe3; R1, R2, R3, R4, R5 = H). Some of these compounds were converted to 1,2,3-trisubstituted trans,trans-indane- and tetrahydroindane derivatives by domino conjugate additions of N, C, and S nucleophiles. With PhCH2NHSiMe3 as an NH3 equivalent, the relative configuration of all 3 newly formed stereogenic centers was controlled (d.e. >90%). With chiral non-racemic ammonia equivalent like benzyl[(S)-phenylethyl]amine and TMS-(R)-AMP, protected diastereomerically pure β-amino esters were obtained, which could easily be deprotected by standard methods to yield the enantiomerically pure β-amino acids II and III. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com