Determination of 3 isothiazolinone preservatives in water-based adhesive by LC-MS/MS method was written by Lu, Xinbo;Xiao, Weiqiang;Xu, Gaoyan;Shi, Chunyun;Jiang, Jian;Zhou, Guojun. And the article was included in Zhongguo Yancao Xuebao in 2015.Product Details of 1003-07-2 This article mentions the following:
A method for determining 3 isothiazolinone preservatives in water-based adhesive by high performance liquid chromatog. tandem mass spectrometry (LC-MS/MS) was developed. The sample was extracted with water, centrifuged, and then analyzed by LCMS/MS and quantified by internal standard method. Results showed that: the linear relationship was good with determination coefficients R2 ≥ 0.9996 in the MI and CMI concentration range of 2.5∼250 ng/mL and in the BIT concentration range of 5∼500 ng/mL. The recoveries of standard addition ranged from 96.3% to 109.6% with relative standard deviation (RSD) of 1.5%∼6.7%. The limit of detection was between 0.011 and 0.015 mg/kg, and that of quantification was between 0.035 and 0.051 mg/kg. It was concluded that this method was suitable for the determination of 3 isothiazolinone preservatives in water-based adhesive. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Product Details of 1003-07-2
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com