Control effect of buspirone combined with atypical antipsychotics on schizophrenia was written by Liu, Fei;Liang, Xue-jun;Jin, Li-juan. And the article was included in Zhongguo Weisheng Gongchengxue in 2021.Reference of 146939-27-7 This article mentions the following:
Objective: To study the control effect of buspirone combined with atypical antipsychotics on schizophrenia. Methods: A total of 116 patients with schizophrenia who were admitted to our hospital from Jan. 2017 to Jan. 2018 were selected and randomly divided into the control group and the observation group, with 58 cases in each group. The control group was treated with atypical antipsychotics alone, while the observation group was treated with buspirone combined with atypical antipsychotics. In the study, the cognitive function, neg. symptoms, and serum biochem. indexes were compared between the two groups before and after treatment. Results: After treatment, the cognitive function scores and biochem. index levels in the observation group were higher than those in the control group, and the neg. symptom scale (SANS) in the observation group was lower than that in the control group, and the differences were statistically significant (all P < 0.05). Conclusion: Buspirone combined with atypical antipsychotics could more effectively improve cognitive function, relieve neg. symptoms and improve serum biochem. indexes in patients with schizophrenia, and the effect was ideal. In the experiment, the researchers used many compounds, for example, 5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one (cas: 146939-27-7Reference of 146939-27-7).
5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one (cas: 146939-27-7) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Reference of 146939-27-7
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com