Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors was written by Jung, Ji Young;Jung, Sun Ho;Koh, Hun Yeong. And the article was included in European Journal of Medicinal Chemistry in 2007.SDS of cas: 119944-89-7 This article mentions the following:
The asym. synthesis of chiral piperazinylpropylisoxazoline analogs, e.g., I and II, was accomplished through a seven-step sequence of reactions, which involved asym. 1,3-dipolar cycloaddition, alkyl chain extension, and reductive amination as key reactions. Chiral ligands I and II exhibited the higher binding affinity and selectivity for the D3 receptor over the D4 receptor than their enantiomers, resp. In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7SDS of cas: 119944-89-7).
1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.SDS of cas: 119944-89-7
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com