Isaksson, Marlene et al. published their research in Contact Dermatitis in 2014 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.COA of Formula: C3H3NOS

Patch testing with serial dilutions of various isothiazolinones in patients hypersensitive to methylchloroisothiazolinone/methylisothiazolinone was written by Isaksson, Marlene;Gruvberger, Birgitta;Bruze, Magnus. And the article was included in Contact Dermatitis in 2014.COA of Formula: C3H3NOS This article mentions the following:

Background : In 2005, methylisothiazolinone (MI) on its own came into use as a preservative. Prior to that, MI was always present together with methylchloroisothiazolinone (MCI). Can the pattern of reactivity to the sep. active ingredients in allergic patients tell us something about the primary sensitizer Objectives : To investigate the potential pattern of cross-reactivity between the isothiazolinones tested, and to find the minimal elicitation concentration for each chem., in order to determine whether the primary sensitizer is MCI or MI. Methods : Patients reacting to MCI/MI and/or MI were addnl. patch tested with MCI/MI, MCI, MI, 2-n-octyl-4-isothiazolin-3-one (OIT) and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (dichloro-OIT) in serial dilutions Results : Three different groups of reactors were seen. One group did not react to MI; another group reacted to both MCI and MI, but had higher patch test reactivity to MCI; and a third group reacted to both MCI and MI with very similar patch test reactivity, but reacted more often to OIT and dichloro-OIT. Conclusions : Patch testing with the active ingredients of MCI/MI in serial dilutions could give information on the primary sensitizer. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2COA of Formula: C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.COA of Formula: C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com