Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones was written by Adibpour, Neda;Khalaj, Ali;Rajabalian, Saeed. And the article was included in European Journal of Medicinal Chemistry in 2010.Synthetic Route of C3H3NOS This article mentions the following:
The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones, e.g., I, and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones, e.g., II, substituted at 4 and/or 3-positions of the Ph moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones with unsubstituted and 4-F substituted Ph rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Synthetic Route of C3H3NOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com