12-year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitis was written by Aalto-Korte, Kristiina;Koskela, Kirsi;Pesonen, Maria. And the article was included in Contact Dermatitis in 2020.Synthetic Route of C3H3NOS This article mentions the following:
Skin diseases are among the most common occupational diseases, but detailed analyses on their epidemiol., diagnosis, and causes are relatively scarce. To analyze data on skin disease in the Finnish Register of Occupational Diseases (FROD) for (1) different diagnosis and (2) main causes of allergic contact dermatitis (ACD). We retrieved data on recognized cases with occupational skin disease (OSD) in the FROD from a 12-yr-period 2005-2016 and used national official labor force data of the year 2012. We analyzed a total of 5265 cases, of which 42% had irritant contact dermatitis (ICD), 35% ACD, 11% contact urticaria/protein contact dermatitis (CU/PCD), and 9% skin infections. The incidence rate of OSD in the total labor force was 18.8 cases/100 000 person years. Skin infections concerned mainly scabies in health care personnel. Twenty-nine per cent of the ACD cases were caused by plastics/resins-related allergens, mainly epoxy chems. Other important causes for ACD were rubber, preservatives, metals, acrylates, and hairdressing chems. Cases of occupational ACD due to isothiazolinones reached a peak in 2014. Our anal. confirms that epoxy products are gaining importance as causes of OSD and the isothiazolinone contact allergy epidemic has started to wane. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Synthetic Route of C3H3NOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com