Rode, H. B. published the artcilePseudosaccharin amine derivatives: Synthesis and elastase inhibitory activity, Safety of 3-Aminobenzo[d]isothiazole 1,1-dioxide, the publication is Pharmazie (2005), 60(10), 723-731, database is CAplus and MEDLINE.
Pseudosaccharin amines were synthesized from saccharin either by the reaction of pseudosaccharin chloride with amines, or via thiosaccharin which was treated with amines yielding thiosaccharinates, and their reaction with glacial acetic acid. This route gave lower yields than the first way. The synthesis of alkyl [(1,1-dioxo-benzo[d]isothiazol-3-yl)amino]alkanoates as possible human leukocyte elastase (HLE) inhibitors was realized by the reaction between amino acid esters and pseudosaccharin chloride. Hydrolysis of the esters was possible under aqueous basic conditions. Selected compounds were screened for elastase inhibitory activity. Compounds (I) and (II) were found to be reversible inhibitors of HLE with Ki values of 45 μM and 60 μM.
Pharmazie published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Safety of 3-Aminobenzo[d]isothiazole 1,1-dioxide.
Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com