Riggin, R. M. published the artcileCharacterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. II. Mutagenicity, Category: isothiazole, the publication is Food and Chemical Toxicology (1983), 21(1), 11-17, database is CAplus and MEDLINE.
All individual components identified in solvent extracts of specific manufacturing lots of saccharin [81-07-2] produced by the Sherwin-Williams process were nonmutagenic. The mutagenic activity of saccharin lot S-1469 was traced to a moderately polar chromatog. fraction representing impurities present in the saccharin at a level of <1.5 ppm, but was not attributable to a single component. In view of the low level of mutagenic activity observed and the low concentration of total impurities in Sherwin-Williams saccharin, the mutagenic material(s) are probably of no significance in animal feeding studies.
Food and Chemical Toxicology published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Category: isothiazole.
Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com