Renwick, A. G. published the artcileThe fate of saccharin impurities: the metabolism and excretion of 3-amino[3-14C]benz[d]isothiazole-1,1-dioxide and 5-chlorosaccharin in the rat, COA of Formula: C7H6N2O2S, the publication is Xenobiotica (1978), 8(8), 487-94, database is CAplus and MEDLINE.
Most (87% of dose) of the 3-aminobenz[d]isothiazole 1,1-dioxide (I) [7668-28-2] (25 mg/kg, orally) was eliminated in the urine of rats within 24 h, 99% of which was unchanged I. 5-Chlorosaccharin [29083-16-7] (80 mg/kg, orally) administered to rats was excreted unchanged, with 76% dose in urine after 24 h, and only 4% in feces. There was <0.5% hydrolysis. Partition experiments indicated that chlorsaccharin had a polarity similar to saccharin, whereas I was more lipophilic, this being reflected in the extent of absorption from the gut and their metabolism
Xenobiotica published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, COA of Formula: C7H6N2O2S.
Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com