Nelson, James J. published the artcileQuantitation of o- and p-sulfamoylbenzoic acids in commercial saccharin by high speed liquid chromatography, Related Products of isothiazole, the publication is EDRO SARAP Research Technical Reports (1976), Paper 45-74, 25 pp., database is CAplus.
A 6 g saccharin [81-07-2] sample was dissolved in 30 mL MeOH, 1.6 mL HNO3 was added, and the mixture was chilled and centrifuged. The precipitate was shaken with 10 mL MeOH and centrifuged. The supernatant was dried under N, mixed with 0.2 mL MeOH, and again dried. An internal standard (p-hydroxybenzoate) was added and the material was subjected to high speed liquid chromatog. on a Dupont SAX column with 0.008M NaNO3 in 0.01M Na tetraborate buffer as the mobile phase. O-sulfamoylbenzoic acid [632-24-6] and p-sulfamoylbenzoic acid [138-41-0] were quantitated with a UV detector and were determined accurately at the 80 and 25 ppm levels, resp. O-toluenesulfonamide [88-19-7], p-toluenesulfonamide [70-55-3], 1,2-benzisothiazoline-1,1-dioxide [936-16-3], and 3-amino-1,2-benzisothiazole S-dioxide [7668-28-2] were extracted from saccharin with Me2CO and determined with an ODS column with isooctane as the mobile phase.
EDRO SARAP Research Technical Reports published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Related Products of isothiazole.
Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com