Mohamed, Abdalla R.’s team published research in Bioorganic Chemistry in 107 | CAS: 7668-28-2

Bioorganic Chemistry published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Application of 3-Aminobenzo[d]isothiazole 1,1-dioxide.

Mohamed, Abdalla R. published the artcileDesign, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities, Application of 3-Aminobenzo[d]isothiazole 1,1-dioxide, the publication is Bioorganic Chemistry (2021), 104569, database is CAplus and MEDLINE.

7,8-Disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione I [R1= Ph, phenylcarbamoyl, p-tolylcarbamoyl, etc.; R2 = bromo, (2,4-dioxo-1H-pyrimidin-6-yl)amino] were selected based on the characteristic pharmacophoric features required for PI3K and B-Raf oncogenes inhibition was synthesized. All the synthesized compounds were evaluated for their in-vitro anticancer activity. I [R1= phenyl; R2 = (2,4-dioxo-1H-pyrimidin-6-yl)amino] and I [R1=p-tolylcarbamoyl; R2 = bromo] displayed an acceptable potent activity according to the DTP-NCI and were further evaluated in the NCI five doses assay. To validate the design, compounds with the highest mean growth inhibition percent were screened against the target PI3Kα and B-RafV600E confirmed their multi-kinase activity. The tested compounds showed promising multi-kinase activity. I [R1= phenyl; R2 = (2,4-dioxo-1H-pyrimidin-6-yl)amino] and I [R1=p-tolylcarbamoyl; R2 = bromo] anticancer effectiveness and multi-kinase activity against PI3Kα and B-RafV600E were consolidated by the inhibition of B-RafWT, EGFR and VEGFR-2 with IC50 in the sub-micromolar range. Further investigations on the most potent I [R1= phenyl; R2 = (2,4-dioxo-1H-pyrimidin-6-yl)amino] and I [R1=p-tolylcarbamoyl; R2 = bromo] were carried out and studied their safety on normal cell line, in-silico profiling and predicted ADME characteristics.

Bioorganic Chemistry published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Application of 3-Aminobenzo[d]isothiazole 1,1-dioxide.

Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com