Ashby, John published the artcileSaccharin: an epigenetic carcinogen/mutagen?, Name: 3-Aminobenzo[d]isothiazole 1,1-dioxide, the publication is Food and Cosmetics Toxicology (1978), 16(2), 95-103, database is CAplus and MEDLINE.
Saccharin [81-07-2] together with 4 of the impurities found in the com. material and a further 9 functional analogs gave neg. results in the Salmonella reverse mutation assay of Ames et al. and the cell-transformation assay of Styles. The significance of these and related in vitro results was evaluated within the context of the ability of com. saccharin to cause bladder cancer in rats and dominant lethal effects in mice. Particular, evidence that the carcinogenicity and the dominant lethal effect associated with saccharin may be mediated by an epigenetic mechanism is evaluated, as is the possible role played by impurities in the generation of these and other biol. effects. The case for separating carcinogens into 2 classes, namely those that operate by a genotypic mechanism and those that elicit their effects via an epigenetic mechanism, is discussed. The compounds evaluated in the current study were saccharin base, Na saccharin [128-44-9], o-toluenesulfonamide [88-19-7], o-sulfonamidobenzoic acid [632-24-6], 5-chlorosaccharin [29083-16-7], 3-iminosaccharin [7668-28-2], 6-chlorosaccharin [46149-10-4], 5-chlorobenzisothiazoline-1,1-dioxide [2515-75-5], 6-aminosaccharin [22094-62-8], 6-nitrosaccharin [22952-24-5], 3-chloro-ψ-saccharin [567-19-1], n3,6-dichloro-ψ-saccharin [15864-53-6], 3-dimethylamino-ψ-saccharin [22716-43-4], 3-piperidinyl-ψ-saccharin [7668-30-6] and 3-pyrrolidino-ψ-saccharin [53541-65-4].
Food and Cosmetics Toxicology published new progress about 7668-28-2. 7668-28-2 belongs to isothiazole, auxiliary class Sulfamide,Amine,Benzothiazole, name is 3-Aminobenzo[d]isothiazole 1,1-dioxide, and the molecular formula is C7H6N2O2S, Name: 3-Aminobenzo[d]isothiazole 1,1-dioxide.
Referemce:
https://en.wikipedia.org/wiki/Isothiazole,
Isothiazole – ScienceDirect.com