Oda, Katsuo published the artcileDevelopment of One-Pot Synthesis of New Antiarthritic Drug Candidate S-2474 with High E-Selectivity, Product Details of C5H11NO2S, the main research area is antiarthritic drug candidate S2474 high E selectivity preparation.
A one-pot synthesis of S-2474 was developed to overcome the problems of a large number of steps, low stereoselectivity, low yield, a large amount of waste, and severe reaction conditions. Aldol-type condensation of 3,5-di-tert-butyl-4-hydroxybenzaldehyde and N-ethyl-γ-sultam was carried out with LDA and then quenched with water. Dehydration proceeded under basic conditions, providing S-2474 directly as a single isomer on the benzylidene double bond. The reaction mechanism appears to involve a quinone methide intermediate. Environmental assessment of the development of this compound is also discussed.
Organic Process Research & Development published new progress about Antiarthritics. 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com