Inagaki, Masanao published the artcileNovel Antiarthritic Agents with 1,2-Isothiazolidine-1,1-dioxide (γ-Sultam) Skeleton: Cytokine Suppressive Dual Inhibitors of Cyclooxygenase-2 and 5-Lipoxygenase, Formula: C5H11NO2S, the main research area is antiarthritic isothiazolidine dioxide sultam preparation; structure activity antiarthritic isothiazolidine dioxide sultam.
Various 1,2-isothiazolidine 1,1-dioxide (γ-sultam) derivatives containing an antioxidant moiety, 2,6-di-tert-butylphenol substituent, were prepared Some compounds, which have a lower alkyl group at the 2-position of the γ-sultam skeleton, showed potent inhibitory effects on both cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LO), as well as production of interleukin (IL)-1 in in vitro assays. They also proved to be effective in several animal arthritic models without any ulcerogenic activities. Among these compounds, (E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-ethyl-1,2-isothiazolidine-1,1-dioxide (S-2474) (I) was selected as an antiarthritic drug candidate and is now under clin. trials. The structure-activity relationships (SAR) examined and some pharmacol. evaluations are described.
Journal of Medicinal Chemistry published new progress about Antiarthritics. 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Formula: C5H11NO2S.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com