October 2022 - Page 7 of 14 - Heterocyclic Building Blocks-Isothiazole

Kyriatsoulis, Apostolos et al. published their patent in 2007 |CAS: 26172-54-3

The Article related to reagent releasing binding protein vitamin d compound assay, dmso release reagent hydroxyvitamin d immunoassay blood serum, dmf release reagent hydroxyvitamin d immunoassay blood serum, n methylpyrrolidone release reagent hydroxyvitamin d immunoassay blood serum, caucassian african human hydroxyvitamin d release reagent immunoassay and other aspects.Synthetic Route of 26172-54-3

On April 12, 2007, Kyriatsoulis, Apostolos; Feldmann, Susanne; Huber, Erasmus; Kobold, Uwe; Puhlmann, Angela; Von Proff, Leopold; Waechter, Nicole published a patent.Synthetic Route of 26172-54-3 The title of the patent was Release reagent for vitamin D compounds. And the patent contained the following:

The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds, as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunol. reagents. 25-Hydroxyvitamin D3-3-hemisuccinate-keyhole hemocyanin conjugates were prepared and used to generate antibodies in sheep. An affinity chromatog. stationary phase was prepared to purify the antibodies. Immunoassay reagents were prepared and used to determine 25-hydroxyvitamin D in serum samples from humans of Caucasian descent and of African descent. When release reagent contained 10 % DMSO, DMF, or N-methylpyrrolidone, the values from the immunoassay correlated very well with values from LC-MS-MS and were independent of the phenotype of the vitamin D-binding protein. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Lewis, Sheldon N. et al. published their patent in 1978 |CAS: 26172-54-3

The Article related to algicides, coating materials, cosmetics and personal care products, detergents, drinking waters, fungicides, leather, lubricating oils, paper, polymers role: uses (uses), soaps role: rct (reactant), ract (reactant or reagent), textiles, wood preservatives and other aspects.Formula: C4H6ClNOS

On August 8, 1978, Lewis, Sheldon N.; Miller, George A.; Law, Andrew B. published a patent.Formula: C4H6ClNOS The title of the patent was 3-Isothiazolones as biocides. And the patent contained the following:

Isothiazolones I (R, R1 = H, halogen, C1-4 alkyl; R2 = optionally substituted C1-18 alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl) (106 compounds) were prepared Thus 79 g (SCH2CH2CONHMe)2 was cyclized in the presence of SO2Cl2 to give 11.5 g I (R = H, R1 = Cl, R2 = Me). I have bactericidal, fungicidal, and algicidal activity. Their use in lubricating oils, cooling water, paints, polymer emulsions, laundry detergents, soaps, cosmetics, paper, leather, textiles, and wood products is illustrated. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Bunnage, Mark E’s team published research in Tetrahedron: Asymmetry in 1995-01-31 | 104322-63-6

Tetrahedron: Asymmetry published new progress about Absolute configuration. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Category: isothiazole.

Bunnage, Mark E.; Burke, Anthony J.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of the N-terminal component of microginin: (2S,3R)-3-amino-2-hydroxydecanoic acid, its (2R,3R)-epimer and (3R)-3-aminodecanoic acid>, Category: isothiazole, the main research area is asym synthesis microginin aminohydroxydecanoic acid; absolute configuration microginin aminohydroxydecanoic acid.

3-Amino-2-hydroxydecanoic acid (AHDA) is a novel amino acid which has been suggested as the N-terminal component of the recently isolated angiotensin-converting enzyme inhibitor microginin. The naturally occurring amino acid was found to possess syn relative stereochem. and (2S,3R) absolute stereochem. when the reported 1H and 13C NMR spectroscopic data and the CD data were compared to the spectroscopic data for synthetic (2R,3R)- and (2S,3R)-AHDA. These studies complete the stereochem. assignment of microginin.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Category: isothiazole.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Sheppard,AureliaC.’s team published research in Tetrahedron Letters in 1988 | 104322-63-6

Tetrahedron Letters published new progress about Amines, keto Role: SPN (Synthetic Preparation), PREP (Preparation). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Davis, Franklin A.; Sheppard, Aurelia C. published the artcile< Oxidation of enamines to α-hydroxy ketones and α-amino ketones using N-sulfonyloxaziridines>, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide, the main research area is enamine oxidation sulfonyloxaziridine; ketone hydroxy amino.

Tri-substituted enamines are oxidized to α-hydroxy ketones by N-sulfonyloxaziridines while di-substituted enamines are oxidized to α-amino ketones. A unified mechanism for the formation of both α-hydroxy ketones and α-amino ketones is proposed.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Bunnage, Mark E’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1993-07-07 | 104322-63-6

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydroxylation. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Reference of 104322-63-6.

Bunnage, Mark E.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of homochiral syn- and anti-3-phenylisoserine derivatives: a practical strategy for the synthesis of the taxol C-13 side chain>, Reference of 104322-63-6, the main research area is taxol side chain asym synthesis; phenyisoserine homochiral derivative; cinnamate conjugate addition lithium methylbenzylbenzylamide; oxaziridine hydroxylation taxol sidechain precursor.

A tandem lithium amide conjugate addition-electrophilic hydroxylation approach to the synthesis of N-benzoyl-3-phenylisoserine Me esters affords a strategy for the practical synthesis of the taxol side chain. Thus, conjugate addition of (R)-PhCHMeN(Li)CH2Ph to (E)-PhCH:CHCO2CMe3 followed by hydroxylation with oxaziridine I gave 86% ester II (95% diastereomeric excess).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Wada, Takeshi’s team published research in Tetrahedron Letters in 1998-09-24 | 104322-63-6

Tetrahedron Letters published new progress about Nucleotides Role: SPN (Synthetic Preparation), PREP (Preparation). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, HPLC of Formula: 104322-63-6.

Wada, Takeshi; Mochizuki, Akira; Sato, Yuichi; Sekine, Mitsuo published the artcile< A convenient method for phosphorylation involving a facile oxidation of H-phosphonate monoesters via bis(trimethylsilyl)phosphites>, HPLC of Formula: 104322-63-6, the main research area is alc phosphonylation sulfonyloxaziridine nucleotide preparation; methylsilylbenzamide camphorsulfonyloxaziridine silylation nucleotide phosphonate; nucleoside phosphorylation oxidation silyl phosphite preparation.

A new convenient route to phosphate monoesters from alcs. has been developed. H-Phosphonate monoesters, which are readily accessible by phosphonylation of the parent alcs., were oxidized with t-BuOOH or N-sulfonyloxaziridines under anhydrous conditions via the corresponding bis(trimethylsilyl) phosphites. N,O-Bis(trimethylsilyl)benzamide (BSB) and (camphor-sulfonyl)oxaziridine (CSO) were found to be highly effective for silylation of H-phosphonates and oxidation of silyl phosphites, resp.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Page, Philip C Bulman’s team published research in Journal of Organic Chemistry in 1997-08-22 | 104322-63-6

Journal of Organic Chemistry published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application of C10H15NO3S.

Page, Philip C. Bulman; Heer, Jag P.; Bethell, Donald; Lund, Andrew; Collington, Eric W.; Andrews, David M. published the artcile< A convenient procedure for the preparation of camphorsulfonyl oxaziridines>, Application of C10H15NO3S, the main research area is camphorsulfonyl oxaziridine preparation.

The title oxaziridines I (X,X = H, OCH2CH2O, OMe, OEt, Cl) were prepared by H2O2 oxidation of the imines II.

Journal of Organic Chemistry published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application of C10H15NO3S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Oka, Natsuhisa’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2013 | 104322-63-6

Chemical Communications (Cambridge, United Kingdom) published new progress about Nucleosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application In Synthesis of 104322-63-6.

Oka, Natsuhisa; Morita, Yasuhiro; Itakura, Yuta; Ando, Kaori published the artcile< Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen>, Application In Synthesis of 104322-63-6, the main research area is nucleoside inosine phosphate diester synthesis phosphitylation phosphoramidite acidic catalyst.

Inosine derivatives bearing a phosphodiester group at the O6-position of the nucleobase were synthesized via phosphitylation of the carbonyl oxygen using phosphoramidites activated by non-nucleophilic acidic activators such as N-(cyanomethyl)pyrrolidinium triflate.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Bunnage, Mark E’s team published research in Tetrahedron in 1994-03-28 | 104322-63-6

Tetrahedron published new progress about Stereoselective synthesis. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Bunnage, Mark E.; Davies, Stephen G.; Goodwin, Christopher J.; Ichihara, Osamu published the artcile< An expeditious asymmetric synthesis of allophenylnorstatine>, Formula: C10H15NO3S, the main research area is asym synthesis allophenylnorstatine; norstatine allophenyl asym synthesis.

The title compound, (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid, a novel amino acid found in the kynostatin class of HIV-1 protease inhibitors, was prepared in 39% overall yield via a tandem conjugate addition-electrophilic hydroxylation protocol using lithium (S)-(α-methylbenzyl)benzylamide and (+)-(camphorsulfonyl)oxaziridine. An unprecedented level of mol. recognition between a homochiral β-amino enolate and a homochiral oxaziridine is identified and the importance of enolate geometry upon hydroxylation stereoselectivity is also addressed.

Tetrahedron published new progress about Stereoselective synthesis. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Pogatchnik, Diana M’s team published research in Tetrahedron Letters in 1997-05-19 | 104322-63-6

Tetrahedron Letters published new progress about Hydroxylation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, SDS of cas: 104322-63-6.

Pogatchnik, Diana M.; Wiemer, David F. published the artcile< Enantioselective synthesis of α-hydroxy phosphonates via oxidation with (camphorsulfonyl)oxaziridines>, SDS of cas: 104322-63-6, the main research area is phosphonate hydroxy enantioselective preparation; hydroxylation enantioselective phosphonate oxaziridine camphorsulfonyl; chiral phosphonate hydroxy preparation.

Reaction of phosphonate anions with enantiomerically pure (camphorsulfonyl)oxaziridines gave nonracemic α-hydroxy phosphonates. This enantioselective hydroxylation methodol. provides convenient access to optically active α-hydroxy phosphonates and their corresponding phosphonic acids. E.g., treating PhCH2P(O)(OMe)2 with (Me3Si)2NNa in THF gave 70% (S)-PhCH(OH)P(O)(OMe)2 (93% ee).

Tetrahedron Letters published new progress about Hydroxylation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, SDS of cas: 104322-63-6.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com