On March 2, 1992, Yagi, Minoru published a patent.Category: isothiazole The title of the patent was Separation of isothiazoline derivatives from their inorganic salts by inclusion complex formation. And the patent contained the following:
Organic compounds, particularly isothiazoline derivatives (I; R1 = H, alkyl, alkenyl, alkynyl, aralkyl; R2, R3 = H, halo; or R2R3 may form a benzene ring), are very effectively separated from a solution containing their inorganic acid salts by adding a compound which exclusively forms inclusion complexes with inorganic acid moiety-ionized organic compounds (sic), and precipitating the inclusion complexes. The process can be applied to other amine inorganic acid salts, eliminates the need for neutralization and extraction, and separates labile, free amines in high yields without decomposition Thus, 1.00 g 2-methyl-4-isothiazolin-3-one (II) hydrochloride was dissolved in 2.5 mL H2O, 1.12 g 2,2′-methylenebis(4-chlorophenol) (III) powder was added under stirring at 25°, the stirring was continued for 30 min at 25°, and the precipitate formed was removed by filtration, washed with H2O, and left to dry at room temperature to give 1.45 g II-III inclusion complex containing 25 weight % II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole
The Article related to isothiazoline inorganic acid salt removal, inclusion complex formation free amine, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: isothiazole
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com