On October 2, 1979, Weiler, Ernest D. published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Isothiazolidin-3-ones. And the patent contained the following:
Isothiazolidinones I (R = H, optionally substituted C1-18 alkyl, phenylalkyl, Ph, naphthyl, cycloalkyl; R1, R3 = halogen, alkyl; R2 = halogen) were prepared Thus 2,4-dimethyl-3-isothiazolinone was chlorinated with Cl to give 68% I (R = R1 = Me, R2 = R3 = Cl), which had a min. inhibitory concentration of 125 ppm against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Rhizopus stolonifer. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to haloisothiazolidinone, bactericide haloisothiazolidinone, fungicide haloisothiazolidinone, isothiazolinone halogenation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com