On December 13, 1977, Weiler, Ernest D.; Miller, George A. published a patent.COA of Formula: C4H6ClNOS The title of the patent was Halogenated 3-isothiazolidinone 1-oxide and 1,1-dioxides. And the patent contained the following:
The title compounds I (R1 = H, C1-18 unsubstituted alkyl, HO, halo, C1-4 carbalkoxy, cyano or carboxy-monosubstituted C1-18 alkyl, C3-8 cycloalkyl, PhCH2, halo C1-4 alkyl, C1-4 alkoxy, nitro or cyano-substituted benzyl, Ph, naphthyl, nitro-substituted Ph or naphthyl; R1, R2 = H, halo; R3 = halo; n = 0, 1) were prepared by halogenation of the corresponding 4-isothiazolin-3-one. Thus, 4-isothiazolin-3-one 1-oxide was brominated with Br to give I (R = R1 = R2 = H, R3 = Br, n = 1) (II). II was fungicidal at 500 ppm, bactericidal at 123 ppm and at 10 lbs/acre controlled monocotyledons by 72%. At 150 ppm II controlled rice blast by 70-89%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS
The Article related to bactericide haloisothiazolidinone oxide, fungicide isothiazolidinone oxide, herbicide isothiazolidinone oxide, algicide isothiazolidinone oxide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com