On August 29, 1974, Weiler, Ernest D. published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Bactericidal and fungicidal 4,5,5-trichloro-3-isothiazolidinones. And the patent contained the following:
Seventeen isothiazolidinones (I; R = C1-10 alkyl, CH2Ph, Ph, C6H4Cl-3, CHMePh, or cyclohexyl; R1 = Me or Cl) were prepared and used as bactericides and fungicides. Thus, (MeNHCOCHMeCH2S)2 was treated with Cl to give 19% I (R = R1 = Me), which was also prepared in 68% yield by chlorination of 2,4-dimethyl-4-isothiazolin-3-one in AcOEt at ≤67°. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to chloroisothiazolidinone bactericide fungicide, isothiazolidinone bactericide, fungicides and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com