On January 4, 2017, Verheyen, Geert R.; Braeken, Els; Van Deun, Koen; Van Miert, Sabine published an article.SDS of cas: 26172-54-3 The title of the article was Evaluation of existing (Q)SAR models for skin and eye irritation and corrosion to use for REACH registration. And the article contained the following:
The performance of the (Q)SAR models Derek Nexus, Toxtree and Case Ultra for the prediction of skin and eye irritation/corrosion is investigated. For irritation and corrosion of the skin, 117 compounds and for the eye, 125 compounds were listed. The balance between the groups pos. and neg. for irritation and corrosion was maintained. The obtained predictions were compared with exptl. data and the numbers of true and false positives and negatives were determined Based on these results several performance parameters of the tested (Q)SAR models were calculated Despite all the efforts to make good and valid models, the results indicate a poor predictivity of the current models: a lot of compounds were not predicted, were out of the applicability domain or were predicted wrong. Considering the authors’ results, it can be concluded that the tested models are not yet sufficiently powerful for implementation. Possibly the training-sets used within the current models are not yet comprehensive enough or the incorporated data are not of enough quality. Although the use of these models as stand-alone evaluation is not recommended, these models can be of value as weight-of-evidence in the context of expert knowledge in an Integrated Approach to Testing and Assessment. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3
The Article related to qsar modeling skin eye irritation corrosion, accuracy, corrosion, irritation, modelling, performance indicator, qsar, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com