On June 17, 1992, Petigara, Ramesh Balubhai; Horton, Isaac Byron published a patent.Computed Properties of 26172-54-3 The title of the patent was Process for preparing 3-isothiazolone compounds. And the patent contained the following:
A process for the preparation of salt-free, and optionally water-free, isothiazolones comprising treating a solution of an acid salt of an isothiazolone with a basic anion exchange resin, preferably a weak base anion exchange resin, and separating the free base isothiazolone solution from the spent resin is claimed. Five different ion exchange resins were evaluated: two strong base anion exchange resins (Amberlite IRA-9OOC-OH and IRA-420C-OH) and 3 weak base anion exchange resins (Amberlite IRA-68, Amberlyst A21 and Diaion WA-30) were used. Thus, chlorination of N-methyl-3-mercaptopropionamide in EtOAc gave a mixture of HCl salts of 5-chloro-2-methyl-3-isothiazolinone and 2-methyl-3-isothiazolone which were neutralized with the described resins. The resultant salt-free isothiazolones are useful as microbicides in environments where even low concentrations of metal salts are undesirable, for example, latex emulsions and corrosion sensitive aqueous systems. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3
The Article related to isothiazolone hydrochloride salt preparation neutralization resin, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com