On July 17, 1991, Petigara, Ramesh Balubhai; Woodruff, Robert Alva; Pendell, Barry Jack; Leister, Norman Andrew published a patent.COA of Formula: C4H6ClNOS The title of the patent was Preparation of salt- and water-free 3-isothiazolones. And the patent contained the following:
The title compounds [I; X = H, alkyl; X1 = H, Cl, alkyl; Y = (un)substituted alkyl] were prepared by neutralization of Im.HmZ (Z = Cl, Br, SO4, FSO3; m = 1, 2) with anhydrous NH3 in an organic solvent. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS
The Article related to isothiazolone anhydrous base preparation, ammonia neutralization isothiazolone acid salt, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com