On October 25, 1995, Petigara, Ramesh Balubbai published a patent.Synthetic Route of 26172-54-3 The title of the patent was Purification of 3-isothiazolones. And the patent contained the following:
The title process for producing substantially separated 5-chloro-2-methyl-3-isothiazolone (CMI) and 2-methyl-3-isothiazolone (MI) from a mixture of their hydrochloride salts comprises heating a mixture of CMI.HCI and MI.HCI in an org, solvent for a period of time necessary to fully dissociate CMI.HCI but insufficient to fully dissociate MI.HCI. CMI free base dissolves in the solvent and the products may recovered by filtration. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3
The Article related to chloromethylisothiazolone purification, methylisothiazolone purification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com