Day: October 26, 2022

On June 30, 2007, Aleksic, Maja; Thain, Emma; Gutsell, Stephen J.; Pease, Camilla K.; Basketter, David A. published an article.Computed Properties of 26172-54-3 The title of the article was The role of non-covalent protein binding in skin sensitization potency of chemicals. And the article contained the following:

Skin sensitization is a delayed hypersensitivity reaction caused by repeated exposure to common natural and synthetic chem. allergens. It is thought that small chem. sensitizers (haptens) are required to form a strong irreversible bond with a self protein/peptide and generate an immunogenic hapten-protein complex in order to be recognized by the immune system and stimulate T cell proliferation. The sensitizers are usually electrophilic chems. that are directly reactive with proteins or reactive intermediates (metabolites) of chem. inert compounds (prohaptens). Sensitizing chems. are also capable of weak, non-covalent association with proteins and there is an ongoing debate about the role of weak interactions of chems. and proteins in the chem. of allergy. The non-covalent interactions are reversible and thus have a major impact on skin/epidermal bioavailability of chem./reactive metabolites. We investigated the relationship between the relative level of non-covalent association to a model protein and their relative potencies as determined by the EC3 values in the murine local lymph node assay (LLNA) for a number of chems. Using human serum albumin as a model protein, we determined that no observable relationship exists between the two parameters for the chems. tested. Therefore, at least for this model protein, non-covalent interactions appear not to be a key determinant of allergen potency. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3

The Article related to skin sensitization potency noncovalent protein binding, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Computed Properties of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 16, 2018, Lin, Lijuan; Zhou, Hecheng; Liu, Jun published a patent.HPLC of Formula: 26172-54-3 The title of the patent was Plastic steel zipper lacquer oil capable of endowing plastic steel zipper with acid resistance, salt spray resistance and water washing resistance. And the patent contained the following:

The title plastic steel zipper lacquer oil comprises first composition and second composition which are packaged sep. The first composition comprises (by weight parts, the same below) epoxy resin 80-83, ethylene glycol monobutyl ether 4-6, black slurry 8-12, leveling agent 0.4-0.6, and adhesion promoter 2-4. The second composition comprises epoxy curing agent 25-35, ethylene glycol monobutyl ether 30-50 and isobutanol 25-35. The invention also provides preparation method and application method of the plastic steel zipper lacquer oil. The inventive plastic steel zipper lacquer oil can be coated on surface of POM plastic steel zipper, and has labor-saving effect and time-saving effect when in use. POM plastic steel zipper coated with the lacquer oil has bright surface, acid resistance, salt spray resistance, and water washing resistance. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to plastic steel zipper lacquer oil capable endowing acid resistance, Coatings, Inks, and Related Products: Related Products and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 1, 2021, Wei, Zhengxi; Fang, Yuhong; Gosztyla, Maya L.; Li, Andrew J.; Huang, Wenwei; LeClair, Christopher A.; Simeonov, Anton; Tao, Dingyin; Xia, Menghang published an article.HPLC of Formula: 26172-54-3 The title of the article was A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers. And the article contained the following:

Chem.-peptide conjugation is the mol. initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatog./UV (HPLC/UV) detection method to quantify chem.-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput, sensitivity and accuracy, an automated 384-well plate-based RapidFire solid-phase extraction (SPE) system coupled with tandem mass spectrometry (MS/MS) DPRA was developed and validated in the presence of a newly designed internal standard Compared to the HPLC/UV-based DPRA, the automated SPE-MS/MS-based DPRA improved throughput from 16 min to 10 s per sample, and substrate peptides usage was reduced from 100 mM to 5μM. When implementing the SPE-MS/MS-based DPRA into a high-throughput platform, we found 10 compounds that depleted lysine peptide and 24 compounds that depleted cysteine peptide (including 7 unreported chems. from 55 compounds we tested) in a concentration-response manner. The adduct formation between cysteine and cinnamic aldehyde and ethylene glycol dimethacrylate were further analyzed using high-performance liquid chromatog. time-of-flight mass spectrometry (HPLC-TOF-MS) to confirm the conjugation. Overall, the automated SPE-MS/MS-based platform is an efficient, economic, and accurate way to detect skin sensitizers. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to skin sensitizer spe msms based dpra, direct peptide reaction assay (dpra), high throughput mass spectrometry, rapidfire-ms/ms, Toxicology: Chemicals (Household, Industrial, General) and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 23, 2019, Yang, Lu; Chen, Jie; Yu, Wangsheng; Yan, Peiyang; Lu, Hai; Zhuang, Huan published a patent.Application of 26172-54-3 The title of the patent was Paper surface sizing solution treatment method, surface sizing solution and coated paper. And the patent contained the following:

Title method comprises: providing a surface sizing solution, wherein the surface sizing solution comprises a starch liquid; testing the pH of the surface sizing solution; determining a dose of adding first bactericide to the surface sizing solution according to a pH value of the surface sizing solution, and adding the dose of the first bactericide to the surface sizing solution to control the microbial content in surface sizing solution The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to sizing solution coated paper, Cellulose, Lignin, Paper, and Other Wood Products: Paper and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On February 7, 2019, Chou, Stephen Y.; Ding, Wei published a patent.COA of Formula: C4H6ClNOS The title of the patent was Devices and methods for examining drug effects on microorganisms and use of cell viability dye for monitoring microorganism viability. And the patent contained the following:

The present invention provides devices, systems, and methods, for performing biol. and chem. assays, in particular, of microorganisms. One aspect of the present invention uses (a) two plates to compress a sample that comprises the microorganisms to be examined into a thin layer, and (b) after (a), an imaging process to count and/or track the microorganisms over a time period or at discrete time points. Another aspect of the present invention uses spacers to control the final sample thickness and hence to assist a determination of the microorganism concentration Yet another aspect of the present invention provides that the drugs to be examined are coated on one or both of the plates, in that the coated drugs are capable of upon contacting the sample, being dissolved and diffuse in the sample. Yet another aspect of the present invention uses a cell viability dye that is added to the sample when the sample is being loaded between the provided two plates and monitoring the microorganism viability with the aid of the dye. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS

The Article related to microorganism drug effect determination device cell viability dye, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.COA of Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 4, 2019, Wang, Songying; Qiu, Zhenming; Huang, Liang; Jiang, Dan published a patent.Formula: C4H6ClNOS The title of the patent was Application of polymer as protease stabilizer in detergents and detergent composition. And the patent contained the following:

Title polymer is an ethoxylated polyethyleneimine. Thus, deionized water was added to the configuration tank; next, 10 weight% of ethoxylated fatty alc. sulfate, 4 weight% of alpha-olefin sulfonate, 7 weight% of ethoxylated fatty alc. 9 and 0.6 weight% of potassium hydroxide were admixed therein, then, protease, 0.05 weight% of 1,2-benzisothiazolin-3-one, 0.05 weight% of 2-methylisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one and 1 weight% of polyacrylic acid were mixed thereto, heated, and stirred to obtain the title detergent composition The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS

The Article related to polymer protease stabilizer detergent composition, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 17, 2016, there was a patent about fire-resistant coating materials.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Water-borne flame-retarding coatings. And the patent contained the following:

The water-borne flame-retarding coating is produced by the steps, mixing water-borne polyurethane resin 50 kg, lactic acid 15 kg, Me silicone oil 3 kg, 2-methyl-4-isothiazoline-3-one hydrochloride 2 kg, diethylene glycol Bu ether 15 kg, flame retardant 8 kg, and water 100 kg, and stirring at 1,500 rpm for around 60 min. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to water borne flame retarding coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 20, 2016, there was a patent about antibacterial agents.Computed Properties of 26172-54-3 The title of the patent was Waterborne flame-retardant coating containing polyurethane and manufacture method. And the patent contained the following:

Title coating is manufactured from waterborne polyurethane resin 30-80, dispersion wetting agent 10-20, defoaming agent 1-5, antibacterial agent 1-5, film-forming additive 10-20, fireproofing agent 1-10, and water 50-150 weight part. Title coating has good fire resistance and broad prospect for industrial application. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3

The Article related to waterborne flame retardant coating polyurethane manufacture, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Computed Properties of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On February 19, 2019, Xie, Zhenwei published a patent.Computed Properties of 26172-54-3 The title of the patent was UV LED water-based ultraviolet curing household furniture coating and preparation method thereof. And the patent contained the following:

Title UV-LED aqueous UV curing household furniture coating comprises: aliphatic urethane acrylate 25~40 parts, aliphatic polyurethane dispersion 45~60 parts, dispersant 0.1 to 0.5 parts, humectant 0.1~0.5 parts, fumed silica 0.1 to 0.5 parts, TS 100 matting powder 1~5 parts, PE wax powder 0.3~0.8 parts, defoamer 0.1~0.5 parts, leveling agent 0.1~0.5 parts, thickener 0.5~3 parts, photoinitiator 2~6 parts, fungicide 0.05~0.3 parts, preservative 0.05~0.3 parts and deionized water 4.8~12.5 parts. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3

The Article related to polyurethane acrylic uv curable furniture coating preparation, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Computed Properties of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 20, 2018, Chen, Zijin published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Antifog-haze low-carbon health coating. And the patent contained the following:

The title coating is prepared from: pure water, pH-adjusting agent, cellulose thickener, dispersion wetting agent, defoamer, super nano-antiradiation anti-fog haze material, nano titanium dioxide, nano far-IR auxiliary agent, heavy calcium carbonate, 828 titanium dioxide, calcined kaolin, antistatic dust remover, VOC-free emulsion or resin, fungicide, nano silver antimicrobial agent and thickening agent. The coating is prepared according to a reasonable formula, and various materials with special functions, such as graphene, nano anion, nano tourmaline, nano titanium dioxide, nano far-IR auxiliary, antistatic dust remover are compounded, so that the resulting coating has good antimildew effect, good dust-proof performance and good antifouling effect and is colorful. The coating is VOC-free, and exhibits good antifog-haze effect, long-lasting air purification, and good antibacterial disinfection effect. The coating can release far IR and neg. oxygen ions. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to fluoropolymer eva polystyrene hydroxyethylcellulose sodium polyacrylate coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com