Day: October 26, 2022

On January 30, 2013, Li, Chengbei published a patent.Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Antiseptic and antimildew composition special for wet tissue, and production method thereof. And the patent contained the following:

The antiseptic and antimildew composition is composed of 10-50% antiseptic aqueous solution 2-15 weight%, antimildew agent 2-6 weight%, rapid germicide 2-5 weight%, solvent 65-80 weight%, additive 0.5-5 weight%, stabilizing agent 0-5 weight%, and addnl. water. The antiseptic is from 2-methylisothiazolinone, 5-chloro-2-methylisothiazolinone, and/or bronopol. The antimildew agent is from 3-iodo-2-propargyl Bu carbamate, and/or p-hydroxybenzoate. The rapid germicide is from p-chloro-3,5-dimethylphenol, and/or 2,4-dichloro-3,5-dimethylphenol. The solvent is from 1,2-propanediol, glycerol, glycol, and/or dipropylene glycol. The additive is from hydrogenated castor oil, nonylphenol polyoxyethylene ether, fatty alc. polyoxyethylene ether, sodium dodecyl ether sulfate, and/or alkyl glycoside. The stabilizing agent is from sodium nitrate, lithium nitrate, potassium nitrate, and/or benzoyl peroxide. The antiseptic and antimildew composition is produced by (1) dissolving antiseptic in deionized water, neutralizing with base to pH 2-4, adding stabilizing agent under stirring, filtering to obtain antiseptic aqueous solution, (2) dissolving antimildew agent in solvent, adding rapid germicide and additive in that order under stirring to obtain antimildew germicide solution, and (3) mixing uniformly both solutions under stirring. The antiseptic and antimildew composition can be specially used in wet tissue, with reasonable formula, and good antiseptic and antimildew effects. The method has the advantages of simple and advanced production process, low cost and suitability for industrialized production The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to antiseptic antimildew composition wet tissue, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On May 21, 2003, Umekawa, Osamu; Takeda, Akinori published a patent.Synthetic Route of 26172-54-3 The title of the patent was Synergistic industrial bactericides/disinfectants/fungicides containing methyl benzimidazolylcarbamate and 2-methyl-4-isothiazolin-3-one, and their use. And the patent contained the following:

Title agents contain Me benzimidazolylcarbamate (I) and/or its HCl salt, and 2-methyl-4-isothiazolin-3-one (II) and/or its salts as active ingredients at an appropriate ratio of exerting synergistic effect. The active ingredients may be added to latexes, aqueous coatings, starch, etc., concomitantly or sep. Thus, aqueous solution containing I.HCl and II.HCl was added to an acrylic emulsion contaminated with Pseudomonas, Flavobacterium, and Penicillium to prevent rotting for 170 days. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3

The Article related to synergistic industrial bactericide fungicide benzimidazolylcarbamate methylisothiazolinone, Agrochemical Bioregulators: Microbial and other aspects.Synthetic Route of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On February 28, 2011, Kato, Masaru; Hida, Kazuo; Fujihara, Takashi; Nagasawa, Akira published an article.Product Details of 26172-54-3 The title of the article was Ferromagnetic Spin Ladder System: Stack of Chlorido-Bridged Dinuclear Copper(II) Complexes with 2-Methylisothiazol-3(2H)-one. And the article contained the following:

A dinuclear copper(II) complex, [{CuIICl(O-mi)}2(μ-Cl)2] [mi = 2-methylisothiazol-3(2H)-one], has been synthesized and its mol. structure in the solid state determined by single-crystal X-ray anal. The crystal consists of centrosym. dinuclear copper(II) units in which each copper(II) ion is doubly bridged by two chloride ions and has a slightly distorted square-planar geometry with a terminal chlorido ligand and a terminal mi ligand coordinated through the oxygen atom. The dinuclear units stack one on top of another to form a one-dimensional two-leg ladder structure. The magnetic susceptibility of the powder was measured in the temperature range 3.0-302 K. It was found that there are ferromagnetic interactions along the rung (in the same direction of the intramol.; Jrung = +5.03 ± 0.03 cm-1) and the leg (in the same direction of the intermol.; Jleg = +1.96 ± 0.02 cm-1) and an antiferromagnetic interaction along the diagonal (Jx = -1.36 ± 0.02 cm-1), the exptl. data being fitted by the numerical calculation for a twelve-site ladder Hamiltonian. In addition, DFT calculations with the UB3LYP functional on the model complex [{CuIICl(O-mi)}2(μ-Cl)2] gave an intramol. magnetic coupling constant J = +28.6 cm-1 and indicated that the spin-d. distribution on O in mi is less than that on the terminal Cl. We conclude that the O-donor ligand at the terminal position plays an essential role in the emerging intramol. ferromagnetic interaction. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to dinuclear copper complex spin ladder magnetic susceptibility crystal structure, Magnetic Phenomena: Magnetic Properties and other aspects.Product Details of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 8, 1988, Grove, Scott L. published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Wood preservatives containing transition metal carboxylates and isothiazolones. And the patent contained the following:

Wood preservatives comprise a transition metal carboxylate and a isothiazolone I [R1 = C1-18 alkyl, alkenyl, or alkynyl, C≤12 cycloalkyl (C3-6 ring); R2, R3 = H, halo, lower alkyl]. A slurry of dithio-N,N-dimethylpropionamide in ethylene dichloride was treated with SO2Cl2 to give I (R1 = Me, R2 = R3 = H)-HCl and I (R1 = Me, R2 = H, R3 = Cl). A wood preservative composition comprised Cu naphthenate 8, I (R1 = octyl, R2 = R3 = Cl) 2, Atlas G 1096 10, Atlas G 3300 2% and the balance mineral spirits. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to metal carboxylate isothiazolone wood preservative, Agrochemical Bioregulators: Invertebrate and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 4, 2017, Verheyen, Geert R.; Braeken, Els; Van Deun, Koen; Van Miert, Sabine published an article.SDS of cas: 26172-54-3 The title of the article was Evaluation of existing (Q)SAR models for skin and eye irritation and corrosion to use for REACH registration. And the article contained the following:

The performance of the (Q)SAR models Derek Nexus, Toxtree and Case Ultra for the prediction of skin and eye irritation/corrosion is investigated. For irritation and corrosion of the skin, 117 compounds and for the eye, 125 compounds were listed. The balance between the groups pos. and neg. for irritation and corrosion was maintained. The obtained predictions were compared with exptl. data and the numbers of true and false positives and negatives were determined Based on these results several performance parameters of the tested (Q)SAR models were calculated Despite all the efforts to make good and valid models, the results indicate a poor predictivity of the current models: a lot of compounds were not predicted, were out of the applicability domain or were predicted wrong. Considering the authors’ results, it can be concluded that the tested models are not yet sufficiently powerful for implementation. Possibly the training-sets used within the current models are not yet comprehensive enough or the incorporated data are not of enough quality. Although the use of these models as stand-alone evaluation is not recommended, these models can be of value as weight-of-evidence in the context of expert knowledge in an Integrated Approach to Testing and Assessment. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to qsar modeling skin eye irritation corrosion, accuracy, corrosion, irritation, modelling, performance indicator, qsar, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 4, 1996, Kurrle-Weittenhiller, Angelika; Schmidt, Axel published a patent.Application of 26172-54-3 The title of the patent was Preservative mixture for diagnostic test fluids. And the patent contained the following:

A preservative mixture, especially for the preservation of test fluids in an α-amylase test kit, contains the Na salt of mercaptopyridine N-oxide combined with another preservative. The disclosed diagnostic test kit contains as preservatives mercaptopyridine N-oxide Na salt, a compound of the isothiazolone group, and especially 2-alkyl-3-(2H)-isothiazolone HCl with 1-8 C atoms in the 2-alkyl group, or a mixture of preservatives. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to amylase determination test kit preservative, mercaptopyridine oxide preservative test kit, isothiazolone compound preservative test kit, Enzymes: Analysis (Determination-Detection) and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On October 10, 2012, Zhang, Weiming; Li, Yaopin; Sun, Dafeng; Ma, Shihong published a patent.SDS of cas: 26172-54-3 The title of the patent was Natural olive oil and its derivative-containing shampoo and its preparation. And the patent contained the following:

The title shampoo contains polyethylene glycol-7 olive oil carboxylic acid sodium 10-20, polyether lauryl sodium sulfate 1-6, sodium olivoyl glutamate 1-10, olivamidopropyl betaine 1-10, ethylene glycol stearate 1-2, oliveamide MEA 1-5, olivoyl hydrolyzed wheat protein 0.1-2, polydimethylsiloxane 0.5-3, polyethylene glycol-7 olivate 0.5-5, sodium chloride 0.1-2, polyquaternium-10 0.5-1, citric acid 0.05-1, hydroxypropyl methylcellulose 0.01-1, methylisothiazolinone 0.01-0.1, chloro-methylisothiazolinone 0.01-0.1, essence 0.1-2% and water. The preparation method comprises heating deionized water in water phase pot to 70~90°C, adding polyquaternium-10 and hydroxypropyl methylcellulose, stirring to effect dissolution, adding polyethylene glycol-7 olive oil carboxylic acid sodium, polyether lauryl sodium sulfate, sodium olivoyl glutamate, olivamidopropyl betaine and olivoyl hydrolyzed wheat protein to dissolve, pumping to vacuum emulsifying pot, adding ethylene glycol stearate, oliveamide MEA and polydimethylsiloxane, stirring to effect dissolution, keeping at the temperature for 20 min, vacuum homogenizing for 5~10 min, stirring to cool to 45°C, removing vacuum, adding olyethylene glycol-7 olivate, sodium chloride, methylisothiazolinone, chloro-methylisothiazolinone and essence, mixing well, and adjusting pH to 6.0-7.5 with citric acid. The title shampoo is characterized with low irritation and high foam. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to olive oil derivative shampoo, Essential Oils and Cosmetics: Hair Preparations and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 25, 1989, Amick, David R. published a patent.Product Details of 26172-54-3 The title of the patent was Stabilization of non-aqueous solutions of 3-isothiazolones as preservatives for cosmetics. And the patent contained the following:

A 0.5-10 weight% solution of isothiazolones [I; R = halo; R1 = H, halo C1-4 alkyl; Y = C1-8 alkyl, (halo-substituted) C2-8 alkenyl or alkynyl, C5-8 cycloalkyl, PhCH2, 3,4-Cl2C6H3CH2, 4-MeOC6H4CH2, 4-ClC6H4CH2, 3,4-Cl2C6H3, 4-MeOC6H4] is stabilized in 90-99 weight% dipropylene glycol, polypropylene glycol, 1,5-pentanediol, or PhCH2OH. A 1% solution of I (R = H; R1 = Cl; Y = Me) (II) in dipropylene glycol showed no loss of II at 65° after 6 wk. A nitrate and nitrate-free hair shampoo was formulated containing 2 ppm active biocide (by addition of a dipropylene glycol solution of a mixture of II and I (R = R1 = H, Y = Me) 3, NaCl 2, and H2O 3%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to isothiazolone solution stabilization cosmetic preservative, Essential Oils and Cosmetics: Hair Preparations and other aspects.Product Details of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 22, 2018, Luo, Weixiao; Gan, Yiwu; Hu, Xiaofei; Bao, Xingyan; Liu, Jiali published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Reagent and method for detecting blood potassium ion by apotryptophanase. And the patent contained the following:

The invention relates to the tech. field of blood pyruvate detection, and particularly to an optimized pyruvate detection reagent with high sensitivity. The reagent comprises reagent 1, reagent 2 and reagent 3. The reagent 1 comprises buffer (tris(hydroxymethyl)aminomethane hydrochloride), EDTA·Na2, sodium chloride, protectant, tryptophan, LDH, NADH, surfactant (lauryldimethylamine oxide), and preservative. The reagent 2 comprises buffer, EDTA·Na2, sodium chloride, protectant, apotryptophanase, and preservative. The reagent 3 comprises potassium chloride, sodium chloride, Triton-100 and preservative. By specifically selecting corresponding interference-removing components for different interfering substances, the reagent has ensured accuracy and specificity, good stability and low cost. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to blood potassium ion apotryptophanase spectrometry, Biochemical Methods: Spectral and Related Methods and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 18, 2017, Zhang, Qiang; Gao, Peng; Zhou, Da; Zhao, Lili; Liu, Yunhui; Huan, Luheng published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Method for improving stability of dyeing grade sodium alginate. And the patent contained the following:

The method comprises the steps, soaking brown algae, washing for first time, digesting, diluting, filtering, calcifying, decalcifying, washing for second time, dewatering to obtain alginic acid, performing solid phase neutralization reaction to obtain sodium alginate, adding solid preservative, granulating, drying, cooling, crushing, adding liquid preservative and solid complexing agent, cooling, and finishing product packaging. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to improvement stability dyeing grade sodium alginate, Industrial Carbohydrates: Mucilages, Gums, and Pectins and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com