On July 28, 1998, Onishi, Toshimasa; Morita, Takashi; Yamamoto, Yoshi; Tojo, Tamaki; Tanaka, Ikuya published a patent.COA of Formula: C4H6ClNOS The title of the patent was Preparation of 3-isothiazolones as microbicides. And the patent contained the following:
Title compounds I [X, Z = H, halo, C1-4 alkyl; Y = C1-8 alkyl, C5-6 cycloalkyl, C≤8 aralkyl, C6 aryl, (substituted) aryl], useful as microbicides (no data), not containing alkali metal salts and H2O produced in neutralization are prepared by neutralization of I hydrohalides with alkali metal bases in organic solvents having solubility of I and no solubility of alkali metal salts in the presence of small amount of H2O, dehydration of the reaction mixtures, and removal of alkali metal salts by solid-liquid separation, recovery of I. 3-Isothiazolone hydrochloride AcOEt solution (5-chloro-2-methyl-4-isothiazolin-3-one (II)/2-methyl-4-isothiazolin-3-one (III) ratio of 4.4/1) was treated with NaHCO3 in the presence of H2O at room temperature for 1 h, dried, separation of a solid from the reaction mixture, and distilled to give 85% 3-isothiazolone with II/III ratio of 4.8/1 containing ≤0.1% H2O and NaCl. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS
The Article related to isothiazolone preparation purification microbicide, neutralization isothiazolone hydrohalide alkali metal base, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com