On October 2, 2001, Onishi, Toshikiyo; Toujou, Tamaki; Noguchi, Keiji published a patent.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preparation of metal-free stable liquid compositions containing 3-isothiazolones as industrial bactericides. And the patent contained the following:
The compositions are prepared by dissolving hydrogen halide salts of 3-isothiazolones in PhOH and washing the solution with water to remove the acids. Thus, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride (I.HCl) and 2-methyl-4-isothiazolin-3-one hydrochloride was dissolved in PhOH, mixed with water, the aqueous phase removed, and the PhOH phase was washed with water to give a solution containing 21.8% I. The solution was left at 40° for 4 wk in a sealed container to show I content 19.6%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to decomposition chloromethylisothiazolinone hydrochloride bactericide phenol water, industrial antibacterial agents and other aspects.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com