On October 2, 2001, Onishi, Toshikiyo; Toujou, Tamaki; Noguchi, Keiji published a patent.COA of Formula: C4H6ClNOS The title of the patent was Preparation of metal-free stable liquid compositions containing 3-isothiazolones as industrial bactericides. And the patent contained the following:
The compositions are prepared by dissolving hydrogen halide salts of 3-isothiazolones in PhOH and heating the solution (with introducing inert gas or subjecting to reduced pressure) to remove the acids. Thus, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride (I.HCl) and 2-methyl-4-isothiazolin-3-one hydrochloride was dissolved in PhOH and heated at 50-60° for 20 h with introducing N to give a solution containing 11.5% I. The solution was left at 40° for 4 wk in a sealed container to show I content 10.4%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS
The Article related to decomposition chloromethylisothiazolinone hydrochloride bactericide heating phenol, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com