On May 12, 2010, Oh, Seok published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Purification of 2-methyl-4-isothiazolin-3-one. And the patent contained the following:
The title purification method comprises: (1) dispersing a product containing 2-methyl-4-isothiazolin-3-one (I) salts and 5-chloro-2-methyl-4-isothiazolin-3-one (II) salts (byproduct) in an organic solvent, (2) adding amines to the solution to generate I and II, further decomposing II at (-20)-30° for 3-72 h, and (3) removing II by filtration and distilling the solution to obtain pure I. I is used as a preservative. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to methylisothiazolinone purification, Pharmaceuticals: Pharmaceutics and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com