On July 17, 2018, Luo, Weixiao; Hu, Xiaofei; Wang, Meili published a patent.HPLC of Formula: 26172-54-3 The title of the patent was Reagent with high interference resistance for detecting uric acid with enzyme. And the patent contained the following:
The reagent with high interference resistance for detecting uric acid with enzymes comprises reagent R1 and reagent R2. The reagent R1 comprises buffer 20, 4-aminoantipyrine 1.2, sodium nitrite 4-8, ion balancer 5-10 mmol/L, ascorbic acid oxidase 3-5 KU/L, heavy metal ion chelating agent 1-2 mmol/L, bovine serum albumin 1-5 g/L, dodecyl tri-Me betaine 1-3, triton-305 1-3 mL/L, and preservative 0.2-0.5 g/L. The reagent R2 comprises buffer 100, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline (F-DAOS) 8-12 mmol/L, uricase 1-2 KU/L, bovine serum albumin 1-5 g/L, peroxidase 5-10 KU/L and preservative 0.2-0.5 g/L. The reagent has very good interference resistance, and can realize very accurate detection, especially for newborn samples. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3
The Article related to interference uric acid ascorbic oxidase uricase peroxidase spectrometry, Biochemical Methods: Reagents and other aspects.HPLC of Formula: 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com