On June 30, 1988, Lindner, Wolfgang published a patent.Category: isothiazole The title of the patent was Process for isolation of isothiazolinone derivatives using strong acids. And the patent contained the following:
Isothiazolinone compounds I (R = C1-3 alkyl; X = halogen; or R = C1-16 alkyl, C5-6 cycloalkyl; X = H) are isolated from tech. mixtures containing ≥1 I compound and/or 4-halo-2-alkyl-3-isothiazolinone and/or 4,5-dihalo-2-alkyl-3-isothiazolinones and/or their halogen addition compounds and/or nitroso compounds, by dissolving the wet mixture in an organic solvent which is slightly miscible or immiscible with water, drying the organic solution, treating with a strong acid, recovering the precipitated I salt, and hydrolyzing it if desired. A 100 g portion of an aqueous tech. solution containing 2-methyl-3-isothiazolinone(II) 4.41, 5-chloro-2-methyl-3-isothiazolinone(III) 10.27, and 4,5-dichloro-2-methyl-3-isothiazolinone (IV) ≈0.3%, was mixed with 100 g AcOEt, the organic layer separated, dried over Na2SO4, the organic solution saturated with HCl, the precipitated salts separated by filtration, and dissolved with stirring in the aqueous phase to give a formulation containing II 4.35, III 9.96, and IV <0.01 g. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole
The Article related to isothiazolinone derivative isolation process, polychloroisothiazolinone separation isothiazolinone purification, acid isothiazolinone purification, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Category: isothiazole
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com