On January 19, 1999, Kim, Sang-Hwan; Park, Jong-Ho; Kim, Jin-Mae; Choi, Ki-Sung; Chow, Myang-Ho; Han, Seung-Jon published a patent.Electric Literature of 26172-54-3 The title of the patent was Preparation of anhydrous isothiazolones as microbicides. And the patent contained the following:
Anhydrous isothiazolones, useful as microbicides (no data), are prepared by extraction from solutions using halo hydrocarbons or nitro hydrocarbons and removal of the halo or nitro hydrocarbons from the extracts An aqueous solution containing ∼3:1 5-chloro-2-methyl-3-isothiazolone.HCl and 2-methyl-3-isothiazolone.HCl was mixed with CH2Cl2 and then the organic layer was evaporated and dissolved into ethylene glycol to give a solution showing H2O content 500 ppm (H2O content of ethylene glycol 450 ppm) and complete storage stability at 65° for ≥16 days. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3
The Article related to isothiazolone anhydrous preparation microbicide, extraction isothiazolone halo nitro hydrocarbon, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com