On April 29, 2009, Jin, Yuechun; Li, Kezhong; Lu, Xueting; Zhang, Xiaolin; Wang, Yu; Zhou, Shuailin; Li, Chao published a patent.Application of 26172-54-3 The title of the patent was Method for continuous production of 3-isothiazolinone derivatives. And the patent contained the following:
The method comprises allowing to react Me acrylate (I) with sulfur and H2S in the first reactor, filtering the reaction liquid to obtain solid, water phase and organic phase containing (SCH2CH2CO2CH3)2 (II) and S(SCH2CH2CO2CH3)2 (III), introducing the solid and water phase to the first reactor, introducing the organic phase into the first counter-current extraction tower, allowing to react compound III with Na2SO3 aqueous solution to obtain compound II, aminating compound II with primary amine (compound IV; NH2R; here: R = C1-C18 alkyl or C3-C18 cycloalkyl) to obtain (SCH2CH2CONHR)2 (compound V; R is defined as above); reacting compound V with Cl2 to obtain the title compound VI (IT-HCl; here: IT is 2-R-4-R1-5-R2-3-isothiazolinone; R is defined as above; R1 and R2 are H or Cl). The method has the advantages of less production equipment, low energy consumption, simplified operation, and suitability for industrialized production The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3
The Article related to isothiazolinone derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com