On April 6, 2011, Jiang, Zhikai; Jiang, Yifan published a patent.Electric Literature of 26172-54-3 The title of the patent was A process for preparing isothiazolone derivatives. And the patent contained the following:
The invention relates to a process for the preparation of isothiazolone derivatives I or II, wherein R1 is H, alkyl, cycloalkyl, or (un)substituted aryl; R2 and R3 independently = H or Cl. For instance, 1,2-benzisothiazol-3(2H)-one was prepared from 2-mercapto-benzonitrile in the presence of Cl2 in 82.28% yield. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3
The Article related to isothiazolone derivative preparation heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com