On April 19, 1991, Igarashi, Yoshio; Suzuki, Tetsuya; Chiku, Yukihiro; Tsunoda, Toshimasa published a patent.Recommanded Product: 26172-54-3 The title of the patent was Preparation and purification of antimicrobial 3-isothiazolones.. And the patent contained the following:
Compositions containing biol. effective amounts of 3-isothiazolones I [R, R1 = H, halo, C1-4 alkyl; Y = C1-8 alkyl, C5-6 cycloaralkyl, C≤8 aralkyl, (substituted) C6 aryl] are prepared by (a) heating crude 3-isothiazolone hydrochlorides in organic solvents followed by removal of solids or (b) treatment of crude 3-isothiazolone hydrochloride with nitrate salts under reduced pressure or inert gases. Nitrosamines and their precursors are removed from the compositions by the above process. A slurry of N, N’-dimethyl-3,3′-dithiodipropionamide (preparation given) was diluted with toluene and chlorinated to give a slurry containing I-HCl (R = H, R1 = Cl, Y = Me) (II), I-HCl (R = R1 = H, Y = Me), and 8080 ppm N-methyl-3-(N’-methyl)aminopropionamide (III). The slurry was refluxed in CHCl3 for 4 h to prepare a composition containing 2326 ppm III with 90.4% recovery of II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Recommanded Product: 26172-54-3
The Article related to isothiazolone microbicide purification, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com