On November 26, 1992, Hahn, Soon Jong; Kim, Jin Man; Park, Young published a patent.Synthetic Route of 26172-54-3 The title of the patent was Preparation of N-alkyl-4-isothiazolin-3-ones from dithiodipropionamides and sulfuryl halides. And the patent contained the following:
Title compounds [I; R1 = Me, Me(CH2)7; R2 = H, Cl], were prepared by (1) treatment of (SCH2CH2CO2H)2 with SOCl2 to give (SCH2CH2COCl)2, (2) treatment of the latter with R1NH2 to give (SCH2CH2CONHR1)2, and (3) treatment of this with SO2X2 (X = halo) in an organic solvent. Thus, [SCH2CH2CONH(CH2)7Me]2 was treated with SO2Cl2 in CH2Cl2 at 0-25° to give 90.5% title compound II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3
The Article related to dithiodipropionamide sulfuryl halide cyclocondensation alkylisothiazolinone, cyclocondensation reaction and other aspects.Synthetic Route of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com