On January 1, 2007, Cuixart Grande, Jesus Maria published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Procedure for preparing 2-alkylisothiazolones and their formulation in stable form alone or in association to other molecules with biocidal activity. And the patent contained the following:
This invention relates to a procedure for preparing 2-alkylisothiazolones of formula I and their formulations in stable forms alone or in association to other mols. with biocidal activity. 2-Alkylisothiazolones may be used as industrial biocides. A procedure for preparing compounds of formula I wherein R is C1-8 alkyl; X and X1 are independently H and Cl; are claimed. These compounds were obtained by cyclization of 3,3′-dithiopropionamides. Several example on formulations of these compounds are also provided. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to alkylisothiazolone preparation formulation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com