On December 7, 1983, Bayer, Horst Otto; Lange, Barry Clifford; Petigara, Ramesh Balubhai published a patent.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Biocidal or biostatic compositions containing 3-isothiazolones and their uses. And the patent contained the following:
Compositions of isothiazolones I (R = R1 = H, halo, C1-4 alkyl; R2 = C1-8 alkyl, C3-6 cycloalkyl) were prepared which containing less than 15 ppm of nitrosamine and nitrosamine precursors as impurities. Thus, MeO2CCH2CH2SSCH2CH2CO2Me was amidated with MeNH2 to give 100% MeNHCOCH2CH2SSCH2CH2CONHMe (II) containing 5000 ppm MeNHCH2CH2CONH2 (III). II was recrystallized from PrOH to give II containing 0 ppm. III. II was cyclized by chlorination and Mg(NO3)2 added to the products to give a composition containing 10.3% by weight 5-chloro-2-methyl-4-isothiazolin-3-one, 5.0% by weight 2-methyl-4-isothiazolin-3-one, and 0 ppm nitrosamine and no nitrosamine precursor. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride
The Article related to isothiazolinone nitrosamine free, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com