On April 25, 1989, Amick, David R. published a patent.Product Details of 26172-54-3 The title of the patent was Stabilization of non-aqueous solutions of 3-isothiazolones as preservatives for cosmetics. And the patent contained the following:
A 0.5-10 weight% solution of isothiazolones [I; R = halo; R1 = H, halo C1-4 alkyl; Y = C1-8 alkyl, (halo-substituted) C2-8 alkenyl or alkynyl, C5-8 cycloalkyl, PhCH2, 3,4-Cl2C6H3CH2, 4-MeOC6H4CH2, 4-ClC6H4CH2, 3,4-Cl2C6H3, 4-MeOC6H4] is stabilized in 90-99 weight% dipropylene glycol, polypropylene glycol, 1,5-pentanediol, or PhCH2OH. A 1% solution of I (R = H; R1 = Cl; Y = Me) (II) in dipropylene glycol showed no loss of II at 65° after 6 wk. A nitrate and nitrate-free hair shampoo was formulated containing 2 ppm active biocide (by addition of a dipropylene glycol solution of a mixture of II and I (R = R1 = H, Y = Me) 3, NaCl 2, and H2O 3%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3
The Article related to isothiazolone solution stabilization cosmetic preservative, Essential Oils and Cosmetics: Hair Preparations and other aspects.Product Details of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com