Bunnage, Mark E.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of homochiral syn- and anti-3-phenylisoserine derivatives: a practical strategy for the synthesis of the taxol C-13 side chain>, Reference of 104322-63-6, the main research area is taxol side chain asym synthesis; phenyisoserine homochiral derivative; cinnamate conjugate addition lithium methylbenzylbenzylamide; oxaziridine hydroxylation taxol sidechain precursor.
A tandem lithium amide conjugate addition-electrophilic hydroxylation approach to the synthesis of N-benzoyl-3-phenylisoserine Me esters affords a strategy for the practical synthesis of the taxol side chain. Thus, conjugate addition of (R)-PhCHMeN(Li)CH2Ph to (E)-PhCH:CHCO2CMe3 followed by hydroxylation with oxaziridine I gave 86% ester II (95% diastereomeric excess).
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydroxylation. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Reference of 104322-63-6.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com