Dowden, James; Moreau, Christelle; Brown, Richard S.; Berridge, Georgina; Galione, Antony; Potter, Barry V. L. published the artcile< Chemical synthesis of the second messenger nicotinic acid and adenine dinucleoside phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate>, Electric Literature of 104322-63-6, the main research area is second messenger nicotinamide adenine nucleotide oligoribonucleotide preparation calcium release; nicotinic acid adenine nucleotide nicotinamide preparation calcium release NADP.
The first single-isomer synthesis of NADP is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success. Significantly, conversion of NADP into the important mammalian second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was achieved. The biol. evaluation of the activity of the release of Ca2+ ions confirms the identity of NAADP. Ca2+ release properties against sea-urchin-egg homogenate and spectroscopic characterization are reported.
Angewandte Chemie, International Edition published new progress about Calcium release channels Role: BCP (Biochemical Process), BSU (Biological Study, Unclassified), BIOL (Biological Study), PROC (Process). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Electric Literature of 104322-63-6.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com