Davis, Franklin; Ulatowski, Terrance G.; Haque, M. Serajul published the artcile< Asymmetric oxidation of chiral enolates in the preparation of acyclic tertiary α-hydroxy amides in high optical purity>, Application In Synthesis of 104322-63-6, the main research area is phenylpropionate enolate asym oxidation; phenylpropionamide enolate asym oxidation; hydroxy amide.
The application of double asym. induction, the asym. oxidation of chiral enolates, to the synthesis of tertiary α-hydroxy amides is described. Asym. oxidation of optically active acyclic, tetra-substituted enolate of I (R = Me) with the readily available (camphorylsulfonyl)oxaziridines (+)(2R,8aS)-II (III) or (-)(2S,8aR)-II (IV) in the presence and absence of HMPA gave tertiary α-hydroxy amide V (R = Me) in high optical purity (88-91% de). In contrast, oxidation of I (R = H) with III or IV gave V (R = H) in low yield and moderate stereoselectivities (30-50% de). The application of III and IV as ‘chiral probes’ of enolate-electrophile reaction mechanisms is discussed.
Journal of Organic Chemistry published new progress about Oxidation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application In Synthesis of 104322-63-6.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com