Clarke, Kenneth; Gleadhill, Brian; Scrowston, Richard M. published an article in Journal of Chemical Research, Synopses. The title of the article was 《Condensed isothiazoles. Part 7. Substitution reactions of 3-methyl-1,2-benzisothiazole and some of its 4- and 5-substituted derivatives》.Reference of 3-Methyl-5-nitrobenzoisothiazole The author mentioned the following in the article:
Some electrophilic formylation, chlorination, bromination and nitration reactions of the methylbenzisothiazole derivatives I (R = R1 = H; R = Br, NH2, NHAc, OH, OMe, R1 = H; R = H, R1 = Br) are described. I (R = H, R1 = Cl, Br, NO2) were prepared by deamination of the appropriate substitution products I (R = NH2, R1 = Cl, Br, NO2). Improved syntheses of 7-chloro- and -bromo-3-methyl-1,2-benzisothiazole are also reported. In addition to this study using 3-Methyl-5-nitrobenzoisothiazole, there are many other studies that have used 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Reference of 3-Methyl-5-nitrobenzoisothiazole) was used in this study.
3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Reference of 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com