Androsov, Dmitry A.’s team published research in Tetrahedron in 2010 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Synthetic Route of C8H6N2O2SSome of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Synthetic Route of C8H6N2O2SOn March 27, 2010, Androsov, Dmitry A.; Solovyev, Andrey Y.; Petrov, Mikhail L.; Butcher, Ray J.; Jasinski, Jerry P. published an article in Tetrahedron. The article was 《A convenient approach towards 2- and 3-aminobenzo[b]thiophenes》. The article mentions the following:

Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler route with primary or secondary amines and sulfur allows a simple, efficient one-pot synthesis of 3-aminobenzo[b]thiophenes. Base-catalyzed transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of primary and secondary amines offers a convenient approach towards 2-aminobenzo[b]thiophenes. In the experiment, the researchers used 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Synthetic Route of C8H6N2O2S)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Synthetic Route of C8H6N2O2SSome of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com